What If a Cortisone Shot in the Knee Doesn’t Work? Here’s Why you’ll need to read this article for you to make the best choice. Knee pain can be debilitating, affecting your ability to perform everyday activities and lowering your quality of life.
Cortisone shots, also known as corticosteroid injections, are a common treatment option for knee pain caused by conditions such as arthritis, meniscus tears, or other inflammatory problems.
These injections are designed to temporarily relieve intense pain by targeting inflammation at the injection site. But what happens when a cortisone shot in the knee doesn’t work? Understanding why this might occur is crucial for determining the next steps in your treatment journey.
To discover additional resources and support, visit this link.
Understanding Cortisone Shots
Cortisone injections are a corticosteroid treatment that mimics the effects of hormones produced by your adrenal glands. These hormones have powerful anti-inflammatory properties, so cortisone shots are often used for painful conditions like knee osteoarthritis, rheumatoid arthritis, or soft tissue injuries.
The injection typically includes a corticosteroid and a local anesthetic for immediate pain relief.
Healthcare providers often use ultrasound guidance to ensure the cortisone shot is administered to the right spot within the affected joint. The goal is to reduce inflammation, improve blood flow, and allow you to resume normal activities.
However, despite their effectiveness for many, cortisone injections aren’t a one-size-fits-all solution.
Why Cortisone Shots Might Not Work

If a cortisone shot doesn’t work, there could be several reasons:
- Misdiagnosed Underlying Problem: Cortisone injections address inflammation but not the root cause of the pain. Conditions like cartilage damage, a meniscus tear, or chronic conditions such as rheumatoid arthritis may not respond to cortisone if the underlying problem isn’t properly diagnosed.
- Severity of Joint Damage: In advanced cases of joint damage, such as severe knee osteoarthritis or significant joint space narrowing, cortisone injections might not provide relief. These conditions may require more aggressive treatments like knee replacement surgery.
- Cortisone Flare: Some patients experience a cortisone flare, where pain temporarily worsens after the injection due to irritation at the injection site. This can mask the effectiveness of the treatment.
- Body’s Response to Cortisone: Not everyone responds to corticosteroids the same way. Factors like your immune system, the type of corticosteroid used, and your overall health can influence the outcome.
- Frequency of Injections: Repeated cortisone injections can lose effectiveness over time. The number of shots you’ve already received might also play a role, as overuse can lead to diminished benefits and potential side effects such as joint damage.
Potential Side Effects of Cortisone Shots

While cortisone injections can be effective, they come with potential side effects, including:
- Temporary Relief: Pain relief may only last for weeks or months.
- Risk of Side Effects: Cortisone can weaken connective tissues, reduce cartilage quality, and increase blood sugar levels in people with diabetes.
- Joint Damage: Overuse of steroid shots can cause long-term joint damage.
- Cortisone Flare: Temporary worsening of pain at the injection site.
Alternative Treatments for Knee Pain
If cortisone shots don’t work, there are several alternative treatments to consider:
- Physical Therapy: Physical therapy focuses on strengthening the muscles around the knee, improving joint stability, and enhancing your range of motion. A tailored program can address underlying causes of pain and improve daily activities.
- Hyaluronic Acid Injections: Often referred to as gel injections, hyaluronic acid can help lubricate the knee joint, reducing friction and pain in arthritic joints.
- Platelet-Rich Plasma (PRP) Injections: PRP injections use your blood to promote healing in the affected joint. This regenerative medicine technique is particularly effective for soft tissue injuries and early-stage arthritis.
- Stem Cell Therapy: Stem cell injections aim to repair damaged cartilage and promote healing. This innovative approach is still being researched but has shown promise for chronic pain and arthritic knees.
- Anti-Inflammatory Medications: Over-the-counter or prescription anti-inflammatory medications can help manage pain and inflammation without the need for injections.
- Surgical Procedures: In severe cases, surgical options like knee replacement or arthroscopic surgery may be the next step. These procedures address structural problems and provide long-term solutions.
- Lifestyle Changes: Weight management, low-impact exercises like swimming or cycling, and dietary changes to reduce inflammation can significantly improve knee pain and overall joint health.
The Role of a Second Opinion
If you’ve tried a cortisone shot without success, it’s a good idea to seek a second opinion. Another healthcare provider might offer a fresh perspective, recommend additional diagnostic tests, or suggest alternative treatments that align with your medical condition and lifestyle.
When to Consider Regenerative Medicine

Regenerative medicine techniques, such as PRP and stem cell therapy, focus on healing the underlying cause of knee pain rather than just masking symptoms. These treatments may be especially beneficial for chronic pain or when traditional medical treatments have failed.
Managing Persistent Pain
Persistent pain after a cortisone shot doesn’t mean you’re out of options. Exploring non-invasive treatments, considering surgical procedures, or trying innovative approaches like stem cell therapy can offer hope for long-term pain relief. Your healthcare provider can guide you in determining the best course of action based on your specific condition.
Conclusion: What’s Next?
If a cortisone shot in the knee doesn’t work, it’s important not to lose hope. The human body is complex, and pain often requires a multi-faceted approach to treatment. Whether it’s through physical therapy, gel injections, PRP, or even surgery, there are numerous paths to explore for effective treatment.
Take the next step toward finding relief by learning more about your condition and exploring alternative treatments. To discover additional resources and support, visit Feel Good Knees. This program offers valuable insights and exercises tailored to knee pain relief, helping you regain your mobility and quality of life.
Q & A Section
Q: Why didn’t my cortisone shot work on my knee?
A: It may not have addressed the root cause of your pain or the severity of joint damage could have reduced its effectiveness. Misdiagnosis or a poor response to corticosteroids could also be factors.
Q: What is the next step if a cortisone shot doesn’t work?
A: Consider alternative treatments like physical therapy, PRP injections, hyaluronic acid injections, or consult your healthcare provider for surgical options.
Q: Why does my knee still hurt after a cortisone injection?
A: Pain may persist due to a cortisone flare, an incorrect injection site, or an advanced underlying condition that requires different treatment.
Q: What is better than cortisone for knee pain?
A: Alternatives include PRP, stem cell therapy, hyaluronic acid injections, physical therapy, or surgical procedures for long-term relief.